Neurological soft signs (NSS) have been shown to be the important biomarkers for schizophrenia. These signs, including motor coordination, sensory integration and disinhibition, were conventionally thought to be minor neurological anomalies without any specific brain regions corresponding for the observed behavioral manifestations. Accumulating imaging findings have suggested these signs are actually associating with specific brain functional network. However, most of these studies have specifically focused on the association of motor coordination signs in patients with schizophrenia and general brain functional connectivity within the cerebral cortex.
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