Appraisal of prodromal symptoms of unipolar depression may complement the traditional cross-sectional approach and provide a longitudinal perspective, according to a staging model of the illness. The gola of this study was to provide an updated systematic review of clinical studies concerned with prodromal symptoms of unipolar depression, according to PRISMA guidelines. Longitudinal studies on prodromal symptoms and signs in adult patients primarily diagnosed with unipolar depression were selected from different sources. Findings were examined separately according to study design (i.e., retrospective or prospective).
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